Journal article
Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma
L Krause, K Nones, KA Loffler, D Nancarrow, H Oey, YH Tang, NJ Wayte, AM Patch, K Patel, S Brosda, S Manning, G Lampe, A Clouston, J Thomas, J Stoye, DJ Hussey, DI Watson, RV Lord, WA Phillips, D Gotley Show all
Carcinogenesis | OXFORD UNIV PRESS | Published : 2015
Abstract
The incidence of esophageal adenocarcinoma (EAC) has risen significantly over recent decades. Although survival has improved, cure rates remain poor, with <20% of patients surviving 5 years. This is the first study to explore methylome, transcriptome and ENCODE data to characterize the role of methylation in EAC. We investigate the genome-wide methylation profile of 250 samples including 125 EAC, 19 Barrett's esophagus (BE), 85 squamous esophagus and 21 normal stomach. Transcriptome data of 70 samples (48 EAC, 4 BE and 18 squamous esophagus) were used to identify changes in methylation associated with gene expression. BE and EAC showed similar methylation profiles, which differed from squamo..
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Grants
Awarded by National Cancer Institute
Funding Acknowledgements
Australian National Health and Medical Research Council (NHMRC; grants APP1021403, 631701, 199600 and 552429); Smart Futures National and International Research Alliances Program (2008004333); National Cancer Institute (5 RO1 CA 001833-02) (its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Cancer Institute); Keith Boden Fellowship to K.N.; NHMRC Principal Research Fellow (1025427) to S.M.G.; Principal Research Fellowship (APP1058522) and Senior Principal Research Fellowship from NHMRC to D.C.W. and N.K.H.; German Academic Exchange Service (DAAD) to S.B.; Translational Research Institute is supported by a grant from the Australian Government.